Description of intramuscular administration has been clarified as: Injection of the drug into muscle, which is then absorbed into the blood. In patients with a poor perfusion state absorption is not predictable and may vary depending on the patient’s size (muscle mass) and their medical condition. There may be decreased absorption in poorly perfused patients, for example in cases of hypothermia and shock. Clinicians should be mindful that there may be a delayed therapeutic response to the medication administered and care must be taken when repeat dosing is required, specifically when administrating morphine or any other medication where overdose could be life-threatening.
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